HOW CALORIEFREE WITH IRVINGIA WORKS!
Weight loss-inducing agents,
be they supplements, hormones or drugs, typically function via only one mechanism. Unfortunately, adipocytes possess numerous
routes to ensure their continued growth and proliferation. These survival characteristics of adipocytes explain why logical
methods to promote weight loss have produced only mediocre results.
Amylase is an enzyme that converts
starch to sugar in the digestive tract. There is an FDA-approved weight loss drug called Acarbose® that inhibits amylase
and thereby reduces the amount of sugar absorbed into the bloodstream. White kidney bean extract does the same thing.44,46
Only moderate weight loss benefits, however, have been shown with amylase inhibitors. Irvingia is an amylase inhibitor, but
this is not its primary mechanism of fat loss induction.
Adiponectin is a hormone that plays a critical
role in metabolic abnormalities that are associated with Type 2 diabetes, obesity, and atherosclerosis. Higher levels of adiponectin
enhance insulin sensitivity, and enhancing insulin sensitivity is important to long-term metabolic health as we age. Adipogenic
transcriptional factors involved with adiponectin are also involved in the formation of new adipocytes, fat burning and endothelial
function. Irvingia increases beneficial adiponectin levels and inhibits adipocyte differentiation mediated through the suppression
of adipogenic transcription factors.
Glycerol-3-phosphate dehydrogenase is an enzyme that facilitates
the conversion of blood glucose into triglycerides that increase adipocyte size. Elevated glycerol-3-phosphate dehydrogenase
might contribute to the increase of triacylglycerol synthesis in obese subjects.56 Irvingia inhibits glycerol-3-phosphate
dehydrogenase, thus reducing the amount of ingested sugars that are converted to body fat.
Leptin is a
hormone secreted from adipocytes. Leptin is much more abundant in the blood of obese individuals. This may at first seem illogical
since leptin functions to turn off appetite while promoting breakdown of triglycerides that bloat adipocytes. One reason obese
people have higher blood levels of leptin is that C-reactive protein binds with leptin and impairs leptin transport across
the blood-brain-barrier and leptin signaling at a cellular level.
The release of C-reactive protein
by adipocytes, a leptin-binding protein, neutralizes the natural adipocyte-controlling effects of leptin. Obese people have
more adipocytes that secrete leptin and C-reactive protein. The result is that more leptin accumulates in the blood of obese
individuals because it is not able to be picked up by leptin receptor sites on cell membranes. Irvingia is associated with
dramatically lower levels of C-reactive protein, thereby unblocking the “leptin resistance” that causes so many
weight loss programs to fail.
Irvingia may induce fat-loss via four different mechanisms:
- It up-regulates the expression of adiponectin, thereby improving insulin sensitivity.
- It
is associated with lower levels of C-reactive protein and helps restore the dual weight control effects of leptin.
- It inhibits glycerol-3-phosphate dehydrogenase, thereby reducing fatty acid formation in the body and inhibiting
the amount of blood glucose that converts to fat.
- It inhibits the enzyme amylase, thus reducing the
amount of ingested starches that will be absorbed as sugar.
Effect of Irvingia on Weight Loss,
Blood Fats and Glucose
In 1990, researchers studied the effects of Irvingia on eleven human Type 2 diabetics.
Compared to baseline, there were significant reductions in blood triglyceride levels (16%), total cholesterol (30%), LDL (39
%), and glucose (38%), while HDL-cholesterol levels were increased by 29% after four-week supplementation. These desirable
biochemical effects were accompanied by improved clinical states.
In 2005, researchers fed guinea pigs a high-fat diet with or without Irvingia. The guinea pigs receiving the Irvingia displayed
a significant increase in beneficial HDL accompanied by a significant decrease in triglycerides and LDL. After three weeks,
the Irvingia-supplemented animals lost more than 7% of their body weight; whereas the control group fed the same high-fat
diet (without Irvingia) showed more than 8% increase in body weight.
In 2006, researchers studied the
effect of Irvingia in rats who were artificially induced to develop diabetes. Just a single oral dose of Irvingia lowered
plasma glucose two hours after treatment.
Another study in 2006 evaluated the effects of Irvingia in
slowing the intestinal absorption of glucose in healthy rats. The results showed a significant reduction in after-meal glucose
blood level and lower subsequent fasting glucose scores.
The first double-blind study in humans occurred
in 2005. Twenty eight of the subjects received Irvingia while twelve were given a placebo. All subjects maintained their normal
calorie intake. After 30 days, subjects taking Irvingia lost 12.3 pounds. The Irvingia group also experienced significant
reductions in total cholesterol, LDL, triglycerides and an increase in HDL.
Based on impressive human data, a dose of 150 mg of Irvingia taken twice a day is all that was
needed to achieve unprecedented clinical results.
CalorieFREE contains 400 mg of Irvingia per capsule.
This supplement should be taken in conjunction
with a healthy diet and regular exercise program. Results may vary.
These statements have not been evaluated by the FDA. CalorieFREE is not intended to diagnose, treat, cure, or prevent
disease or medical conditions.
